Chromone derivatives exhibiting high absorbance values in the UVA/UVB region were synthesized, and their photoprotective properties were evaluated. Chromones were prepared according to known literature procedures and characterized by high resolution mass spectrometry, infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy. The in vitro solar protection factor (SPF) was determined by the Mansur method and cytotoxicity was evaluated using the sulforhodamine B assay. Two of the chromones synthesized demonstrated suitable SPF values and displayed no cytotoxic effect towards MRC-5 human fibroblasts at the tested concentrations, indicating great potential for future in vivo assays and clinical trials. Finally, the lead compound was incorporated into a nanoemulsion. Nanoemulsions showed high droplet size homogeneity and excellent stability. Chromones bearing methoxy substituents were found to be the most promising compounds with ideal photoprotective properties desirable for utilization and incorporation in sunscreen formulations.

RESUMO Este texto propõe a trazer à tona alguns aspectos dos estudos do budismo e de sua filosofia no Brasil, que têm sido, de alguma forma, negligenciados ou tratados de modo pouco condizente com a proposta com que este filosofar foi inicialmente concebido. Não se trata de convencer ou "converter" acadêmicos brasileiros a pensarem de maneira similar aos eruditos budistas, mas simplesmente destacar pontos que parecem relevantes para dar continuidade a um debate que já vem sendo estabelecido, particularmente na última década. Com este propósito, serão levantadas questões como as motivações e métodos do fazer filosófico, o dogmatismo, a ética e formas de transmissão de conhecimento.

ABSTRACT This text aims to highlight some aspects of the study of Buddhism and its philosophy in Brazil, which have been either neglected or treated in a manner that is incongruous with the proposal upon which this philosophy was initially conceived. The motivation here is not to convince or "convert" Brazilian scholars to think in a similar way to the Buddhist scholars, but simply to bring out points that seem to be relevant to foster the debate that has already been established, particularly in the last decade. For this purpose, issues regarding motivation and method in philosophical work, dogmatism, ethics and modes of knowledge transmission will be raised.